Oncogenomics - key publications - Queensland Institute of Medical Research

Melanoma and melanoma-associated phenotypes of pigmentation and naevi

Nevi, family history, and fair skin increase the risk of second primary melanoma.

Siskind V, Hughes MC, Palmer JM, Symmons JM, Aitken JF, Martin NG, Hayward NK, Whiteman DC.

Invest Dermatol. 2011 Feb;131(2):461-7. Epub 2010 Oct 14. PMID: 20944647 [PubMed - in process]

Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study.

Demenais F, Mohamdi H, Chaudru V, Goldstein AM, Newton Bishop JA, Bishop DT, Kanetsky PA, Hayward NK, Gillanders E, Elder DE, Avril MF, Azizi E, van Belle P, Bergman W, Bianchi-Scarrà G, Bressac-de Paillerets B, Calista D, Carrera C, Hansson J, Harland M, Hogg D, Höiom V, Holland EA, Ingvar C, Landi MT, Lang JM, Mackie RM, Mann GJ, Ming ME, Njauw CJ, Olsson H, Palmer J, Pastorino L, Puig S, Randerson-Moor J, Stark M, Tsao H, Tucker MA, van der Velden P, Yang XR, Gruis N; Melanoma Genetics Consortium.

Natl Cancer Inst. 2010 Oct 20;102(20):1568-83. Epub 2010 Sep 28. PMID: 20876876 [PubMed - indexed for MEDLINE]Free PMC Article Free text

IRF4 variants have age-specific effects on nevus count and predispose to melanoma.

Duffy DL, Iles MM, Glass D, Zhu G, Barrett JH, Höiom V, Zhao ZZ, Sturm RA, Soranzo N, Hammond C, Kvaskoff M, Whiteman DC, Mangino M, Hansson J, Newton-Bishop JA; GenoMEL, Bataille V, Hayward NK, Martin NG, Bishop DT, Spector TD, Montgomery GW.

Am J Hum Genet. 2010 Jul 9;87(1):6-16. Epub 2010 Jun 17. PMID: 20602913 [PubMed - indexed for MEDLINE]Free PMC Article Free text

A versatile gene-based test for genome-wide association studies.

Liu JZ, McRae AF, Nyholt DR, Medland SE, Wray NR, Brown KM; AMFS Investigators, Hayward NK, Montgomery GW, Visscher PM, Martin NG, Macgregor S.

Am J Hum Genet. 2010 Jul 9;87(1):139-45. PMID: 20598278 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Characterization of the Melanoma miRNAome by Deep Sequencing.

Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC, Parsons PG, Schmidt C, Sturm RA, Hayward NK.

PLoS One. 2010 Mar 12;5(3):e9685. PMID: 20300190 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244).

Dry JR, Pavey S, Pratilas CA, Harbron C, Runswick S, Hodgson D, Chresta C, McCormack R, Byrne N, Cockerill M, Graham A, Beran G, Cassidy A, Haggerty C, Brown H, Ellison G, Dering J, Taylor BS, Stark M, Bonazzi V, Ravishankar S, Packer L, Xing F, Solit DB, Finn RS, Rosen N, Hayward NK, French T, Smith PD.

Cancer Res. 2010 Mar 15;70(6):2264-73. Epub 2010 Mar 9. PMID: 20215513 [PubMed - indexed for MEDLINE]

Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma.

Duffy DL, Zhao ZZ, Sturm RA, Hayward NK, Martin NG, Montgomery GW.

Invest Dermatol. 2010 Feb;130(2):520-8. Epub 2009 Aug 27. PMID: 19710684 [PubMed - indexed for MEDLINE]Free Article

Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.

Falchi M, Bataille V, Hayward NK, Duffy DL, Bishop JA, Pastinen T, Cervino A, Zhao ZZ, Deloukas P, Soranzo N, Elder DE, Barrett JH, Martin NG, Bishop DT, Montgomery GW, Spector TD.

Nat Genet. 2009 Aug;41(8):915-9. Epub 2009 Jul 5. PMID: 19578365 [PubMed - indexed for MEDLINE]

Genome-wide association study identifies three loci associated with melanoma risk.

Bishop DT, Demenais F, Iles MM, Harland M, Taylor JC, Corda E, Randerson-Moor J, Aitken JF, Avril MF, Azizi E, Bakker B, Bianchi-Scarrà G, Bressac-de Paillerets B, Calista D, Cannon-Albright LA, Chin-A-Woeng T, Debniak T, Galore-Haskel G, Ghiorzo P, Gut I, Hansson J, Hocevar M, Höiom V, Hopper JL, Ingvar C, Kanetsky PA, Kefford RF, Landi MT, Lang J, Lubiński J, Mackie R, Malvehy J, Mann GJ, Martin NG, Montgomery GW, van Nieuwpoort FA, Novakovic S, Olsson H, Puig S, Weiss M, van Workum W, Zelenika D, Brown KM, Goldstein AM, Gillanders EM, Boland A, Galan P, Elder DE, Gruis NA, Hayward NK, Lathrop GM, Barrett JH, Bishop JA.

Nat Genet. 2009 Aug;41(8):920-5. Epub 2009 Jul 5. PMID: 19578364 [PubMed - indexed for MEDLINE]Free PMC Article Free text

The association between MC1R genotype and BRAF mutation status in cutaneous melanoma: findings from an Australian population.

Hacker E, Hayward NK, Dumenil T, James MR, Whiteman DC.

Invest Dermatol. 2010 Jan;130(1):241-8. Epub . PMID: 19571821 [PubMed - indexed for MEDLINE]Free Article

Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo.

Tonks ID, Mould A, Nurcombe V, Cool SM, Walker GJ, Hacker E, Keith P, Schroder WA, Cotterill A, Hayward NK, Kay GF.

Pigment Cell Melanoma Res. 2009 Jun;22(3):328-30. Epub 2009 Feb 25. No abstract available. PMID: 19243574 [PubMed - indexed for MEDLINE]

Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma.

Bonazzi VF, Irwin D, Hayward NK.

Genes Chromosomes Cancer. 2009 Jan;48(1):10-21. PMID: 18803327 [PubMed - indexed for MEDLINE]

Common sequence variants on 20q11.22 confer melanoma susceptibility.

Brown KM, Macgregor S, Montgomery GW, Craig DW, Zhao ZZ, Iyadurai K, Henders AK, Homer N, Campbell MJ, Stark M, Thomas S, Schmid H, Holland EA, Gillanders EM, Duffy DL, Maskiell JA, Jetann J, Ferguson M, Stephan DA, Cust AE, Whiteman D, Green A, Olsson H, Puig S, Ghiorzo P, Hansson J, Demenais F, Goldstein AM, Gruis NA, Elder DE, Bishop JN, Kefford RF, Giles GG, Armstrong BK, Aitken JF, Hopper JL, Martin NG, Trent JM, Mann GJ, Hayward NK.

Nat Genet. 2008 Jul;40(7):838-40. Epub 2008 May 18. PMID: 18488026 [PubMed - indexed for MEDLINE]Free PMC Article Free text

A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.

Han J, Kraft P, Nan H, Guo Q, Chen C, Qureshi A, Hankinson SE, Hu FB, Duffy DL, Zhao ZZ, Martin NG, Montgomery GW, Hayward NK, Thomas G, Hoover RN, Chanock S, Hunter DJ.

PLoS Genet. 2008 May 16;4(5):e1000074. PMID: 18483556 [PubMed - indexed for MEDLINE]Free PMC Article Free text

A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color.

Sturm RA, Duffy DL, Zhao ZZ, Leite FP, Stark MS, Hayward NK, Martin NG, Montgomery GW.

Am J Hum Genet. 2008 Feb;82(2):424-31. Epub 2008 Jan 24. PMID: 18252222 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF.

Packer LM, Pavey SJ, Boyle GM, Stark MS, Ayub AL, Rizos H, Hayward NK.

Int J Cancer. 2007 Aug 15;121(4):784-90. PMID: 17450523 [PubMed - indexed for MEDLINE]

Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.

Stark M, Hayward N.

Cancer Res. 2007 Mar 15;67(6):2632-42. PMID: 17363583 [PubMed - indexed for MEDLINE]Free Article

A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation.

Duffy DL, Montgomery GW, Chen W, Zhao ZZ, Le L, James MR, Hayward NK, Martin NG, Sturm RA.

Am J Hum Genet. 2007 Feb;80(2):241-52. Epub 2006 Dec 20. PMID: 17236130 [PubMed - indexed for MEDLINE]Free PMC Article Free text

A genome-wide scan for naevus count: linkage to CDKN2A and to other chromosome regions.

Zhu G, Montgomery GW, James MR, Trent JM, Hayward NK, Martin NG, Duffy DL.

Eur J Hum Genet. 2007 Jan;15(1):94-102. Epub 2006 Oct 25. PMID: 17063143 [PubMed - indexed for MEDLINE]Free Article

High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL.

Goldstein AM, Chan M, Harland M, Gillanders EM, Hayward NK, Avril MF, Azizi E, Bianchi-Scarra G, Bishop DT, Bressac-de Paillerets B, Bruno W, Calista D, Cannon Albright LA, Demenais F, Elder DE, Ghiorzo P, Gruis NA, Hansson J, Hogg D, Holland EA, Kanetsky PA, Kefford RF, Landi MT, Lang J, Leachman SA, Mackie RM, Magnusson V, Mann GJ, Niendorf K, Newton Bishop J, Palmer JM, Puig S, Puig-Butille JA, de Snoo FA, Stark M, Tsao H, Tucker MA, Whitaker L, Yakobson E; Melanoma Genetics Consortium (GenoMEL).

Cancer Res. 2006 Oct 15;66(20):9818-28. PMID: 17047042 [PubMed - indexed for MEDLINE]Free Article

Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents.

Goldstein AM, Chan M, Harland M, Hayward NK, Demenais F, Bishop DT, Azizi E, Bergman W, Bianchi-Scarra G, Bruno W, Calista D, Albright LA, Chaudru V, Chompret A, Cuellar F, Elder DE, Ghiorzo P, Gillanders EM, Gruis NA, Hansson J, Hogg D, Holland EA, Kanetsky PA, Kefford RF, Landi MT, Lang J, Leachman SA, MacKie RM, Magnusson V, Mann GJ, Bishop JN, Palmer JM, Puig S, Puig-Butille JA, Stark M, Tsao H, Tucker MA, Whitaker L, Yakobson E; Lund Melanoma Study Group; Melanoma Genetics Consortium (GenoMEL).

Med Genet. 2007 Feb;44(2):99-106. Epub 2006 Aug 11. PMID: 16905682 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Cutaneous melanoma susceptibility and progression genes.

de Snoo FA, Hayward NK.

Cancer Lett. 2005 Dec 18;230(2):153-86. Review. PMID: 16297704 [PubMed - indexed for MEDLINE]

A genome scan for eye color in 502 twin families: most variation is due to a QTL on chromosome 15q.

Zhu G, Evans DM, Duffy DL, Montgomery GW, Medland SE, Gillespie NA, Ewen KR, Jewell M, Liew YW, Hayward NK, Sturm RA, Trent JM, Martin NG.

Twin Res. 2004 Apr;7(2):197-210. PMID: 15169604 [PubMed - indexed for MEDLINE]

Microarray expression profiling in melanoma reveals a BRAF mutation signature.

Pavey S, Johansson P, Packer L, Taylor J, Stark M, Pollock PM, Walker GJ, Boyle GM, Harper U, Cozzi SJ, Hansen K, Yudt L, Schmidt C, Hersey P, Ellem KA, O'Rourke MG, Parsons PG, Meltzer P, Ringnér M, Hayward NK.

Oncogene. 2004 May 20;23(23):4060-7. PMID: 15048078 [PubMed - indexed for MEDLINE]

Interactive effects of MC1R and OCA2 on melanoma risk phenotypes.

Duffy DL, Box NF, Chen W, Palmer JS, Montgomery GW, James MR, Hayward NK, Martin NG, Sturm RA.

Hum Mol Genet. 2004 Feb 15;13(4):447-61. Epub 2004 Jan 6. PMID: 14709592 [PubMed - indexed for MEDLINE]Free Article

Localization of a novel melanoma susceptibility locus to 1p22.

Gillanders E, Juo SH, Holland EA, Jones M, Nancarrow D, Freas-Lutz D, Sood R, Park N, Faruque M, Markey C, Kefford RF, Palmer J, Bergman W, Bishop DT, Tucker MA, Bressac-de Paillerets B, Hansson J, Stark M, Gruis N, Bishop JN, Goldstein AM, Bailey-Wilson JE, Mann GJ, Hayward N, Trent J; Lund Melanoma Study Group; Melanoma Genetics Consortium.

Am J Hum Genet. 2003 Aug;73(2):301-13. Epub 2003 Jul 3. PMID: 12844286 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Genetics of melanoma predisposition.

Hayward NK.

Oncogene. 2003 May 19;22(20):3053-62. Review. PMID: 12789280 [PubMed - indexed for MEDLINE]

Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma.

Whiteman DC, Watt P, Purdie DM, Hughes MC, Hayward NK, Green AC.

Natl Cancer Inst. 2003 Jun 4;95(11):806-12. PMID: 12783935 [PubMed - indexed for MEDLINE]Free Article

High frequency of BRAF mutations in nevi.

Pollock PM, Harper UL, Hansen KS, Yudt LM, Stark M, Robbins CM, Moses TY, Hostetter G, Wagner U, Kakareka J, Salem G, Pohida T, Heenan P, Duray P, Kallioniemi O, Hayward NK, Trent JM, Meltzer PS.

Nat Genet. 2003 Jan;33(1):19-20. Epub 2002 Nov 25. PMID: 12447372 [PubMed - indexed for MEDLINE]

Geographical variation in the penetrance of CDKN2A mutations for melanoma

Bishop DT, Demenais F, Goldstein AM, Bergman W, Bishop JN, Bressac-de Paillerets B, Chompret A, Ghiorzo P, Gruis N, Hansson J, Harland M, Hayward N, Holland EA, Mann GJ, Mantelli M, Nancarrow D, Platz A, Tucker MA; Melanoma Genetics Consortium.

Natl Cancer Inst. 2002 Jun 19;94(12):894-903. PMID: 12072543 [PubMed - indexed for MEDLINE]Free Article

Melanoma in adolescents: a case-control study of risk factors in Queensland, Australia.

Youl P, Aitken J, Hayward N, Hogg D, Liu L, Lassam N, Martin N, Green A.

Int J Cancer. 2002 Mar 1;98(1):92-8. PMID: 11857391 [PubMed - indexed for MEDLINE]

p16INK4A and p14ARF tumour suppressors in melanoma: lessons from the mouse.

Walker GJ, Hayward NK.

Lancet. 2002 Jan 5;359(9300):7-8. No abstract available. PMID: 11809177 [PubMed - indexed for MEDLINE]

MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations.

Box NF, Duffy DL, Chen W, Stark M, Martin NG, Sturm RA, Hayward NK.

Am J Hum Genet. 2001 Oct;69(4):765-73. Epub 2001 Aug 8. PMID: 11500805 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Melanocortin-1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype?

Palmer JS, Duffy DL, Box NF, Aitken JF, O'Gorman LE, Green AC, Hayward NK, Martin NG, Sturm RA.

Am J Hum Genet. 2000 Jan;66(1):176-86. PMID: 10631149 [PubMed - indexed for MEDLINE]Free PMC Article Free text

A major quantitative-trait locus for mole density is linked to the familial melanoma gene CDKN2A: a maximum-likelihood combined linkage and association analysis in twins and their sibs.

Zhu G, Duffy DL, Eldridge A, Grace M, Mayne C, O'Gorman L, Aitken JF, Neale MC, Hayward NK, Green AC, Martin NG.

Am J Hum Genet. 1999 Aug;65(2):483-92. PMID: 10417291 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Functional reassessment of P16 variants using a transfection-based assay.

Walker GJ, Gabrielli BG, Castellano M, Hayward NK.

Int J Cancer. 1999 Jul 19;82(2):305-12. PMID: 10389768 [PubMed - indexed for MEDLINE]

CDKN2A variants in a population-based sample of Queensland families with melanoma.

Aitken J, Welch J, Duffy D, Milligan A, Green A, Martin N, Hayward N.

Natl Cancer Inst. 1999 Mar 3;91(5):446-52. PMID: 10070944 [PubMed - indexed for MEDLINE]Free Article

Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds.

Flores JF, Pollock PM, Walker GJ, Glendening JM, Lin AH, Palmer JM, Walters MK, Hayward NK, Fountain JW.

Oncogene. 1997 Dec 11;15(24):2999-3005. PMID: 9416844 [PubMed - indexed for MEDLINE]Free Article

Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors.

Gonzalgo ML, Bender CM, You EH, Glendening JM, Flores JF, Walker GJ, Hayward NK, Jones PA, Fountain JW.

Cancer Res. 1997 Dec 1;57(23):5336-47. PMID: 9393758 [PubMed - indexed for MEDLINE]Free Article

CDKN2A/p16 is inactivated in most melanoma cell lines.

Castellano M, Pollock PM, Walters MK, Sparrow LE, Down LM, Gabrielli BG, Parsons PG, Hayward NK.

Cancer Res. 1997 Nov 1;57(21):4868-75. PMID: 9354451 [PubMed - indexed for MEDLINE]Free Article

Germline CDKN2A mutations in childhood melanoma.

Whiteman DC, Milligan A, Welch J, Green AC, Hayward NK.

Natl Cancer Inst. 1997 Oct 1;89(19):1460. No abstract available. PMID: 9326917 [PubMed - indexed for MEDLINE]Free Article

Restoration of CDKN2A into melanoma cells induces morphologic changes and reduction in growth rate but not anchorage-independent growth reversal.

Castellano M, Gabrielli BG, Hussussian CJ, Dracopoli NC, Hayward NK.

Invest Dermatol. 1997 Jul;109(1):61-8. PMID: 9204956 [PubMed - indexed for MEDLINE]

The CDKN2A (p16) gene and human cancer.

Foulkes WD, Flanders TY, Pollock PM, Hayward NK.

Mol Med. 1997 Jan;3(1):5-20. Review. PMID: 9132280 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma.

van Elsas A, Zerp SF, van der Flier S, Krüse KM, Aarnoudse C, Hayward NK, Ruiter DJ, Schrier PI.

Am J Pathol. 1996 Sep;149(3):883-93. PMID: 8780392 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions.

Pollock PM, Pearson JV, Hayward NK.

Genes Chromosomes Cancer. 1996 Feb;15(2):77-88. Review. PMID: 8834170 [PubMed - indexed for MEDLINE]

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma.

Zuo L, Weger J, Yang Q, Goldstein AM, Tucker MA, Walker GJ, Hayward N, Dracopoli NC.

Nat Genet. 1996 Jan;12(1):97-9. No abstract available. PMID: 8528263 [PubMed - indexed for MEDLINE]

Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds.

Walker GJ, Hussussian CJ, Flores JF, Glendening JM, Haluska FG, Dracopoli NC, Hayward NK, Fountain JW.

Hum Mol Genet. 1995 Oct;4(10):1845-52. PMID: 8595405 [PubMed - indexed for MEDLINE]

Evidence for u.v. induction of CDKN2 mutations in melanoma cell lines.

Pollock PM, Yu F, Qiu L, Parsons PG, Hayward NK.

Oncogene. 1995 Aug 17;11(4):663-8. PMID: 7651729 [PubMed - indexed for MEDLINE]

A genetic model of melanoma tumorigenesis based on allelic losses.

Walker GJ, Palmer JM, Walters MK, Hayward NK.

Genes Chromosomes Cancer. 1995 Feb;12(2):134-41. PMID: 7535086 [PubMed - indexed for MEDLINE]

Incidence of familial melanoma and MLM2 gene.

Battistutta D, Palmer J, Walters M, Walker G, Nancarrow D, Hayward N.

Lancet. 1994 Dec 10;344(8937):1607-8. PMID: 7983995 [PubMed - indexed for MEDLINE]

Multiple endocrine neoplasia

Alterations in gene expression in MEN1-associated insulinoma development.

Serewko-Auret MM, Mould AW, Loffler KA, Duncan R, Kay GF, Hayward NK.

Pancreas. 2010 Nov;39(8):1140-6. PMID: 20531244 [PubMed - in process]

Global expression profiling of sex cord stromal tumors from Men1 heterozygous mice identifies altered TGF-beta signaling, decreased Gata6 and increased Csf1r expression.

Mould AW, Duncan R, Serewko-Auret M, Loffler KA, Biondi C, Gartside M, Kay GF, Hayward NK.

Int J Cancer. 2009 Mar 1;124(5):1122-32. PMID: 19058182 [PubMed - indexed for MEDLINE]

Global expression profiling of murine MEN1-associated tumors reveals a regulatory role for menin in transcription, cell cycle and chromatin remodelling.

Mould AW, Duncan R, Serewko-Auret M, Loffler KA, Biondi C, Gartside M, Kay GF, Hayward NK.

Int J Cancer. 2007 Aug 15;121(4):776-83. PMID: 17455252 [PubMed - indexed for MEDLINE]

Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1.

Loffler KA, Biondi CA, Gartside M, Waring P, Stark M, Serewko-Auret MM, Muller HK, Hayward NK, Kay GF.

Int J Cancer. 2007 Jan 15;120(2):259-67. PMID: 17044021 [PubMed - indexed for MEDLINE]

Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues.

Biondi CA, Gartside MG, Waring P, Loffler KA, Stark MS, Magnuson MA, Kay GF, Hayward NK.

Mol Cell Biol. 2004 Apr;24(8):3125-31. PMID: 15060136 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

Hughes CM, Rozenblatt-Rosen O, Milne TA, Copeland TD, Levine SS, Lee JC, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA, Kay GF, Hayward NK, Hess JL, Meyerson M.

Mol Cell. 2004 Feb 27;13(4):587-97. PMID: 14992727 [PubMed - indexed for MEDLINE]

Identification of MEN1 gene mutations in families with MEN 1 and related disorders.

Bergman L, Teh B, Cardinal J, Palmer J, Walters M, Shepherd J, Cameron D, Hayward N.

Br J Cancer. 2000 Oct;83(8):1009-14. PMID: 10993647 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Identification of somatic mutations of the MEN1 gene in sporadic endocrine tumours.

Bergman L, Boothroyd C, Palmer J, Grimmond S, Walters M, Teh B, Shepherd J, Hartley L, Hayward N.

Br J Cancer. 2000 Oct;83(8):1003-8. PMID: 10993646 [PubMed - indexed for MEDLINE]Free PMC Article Free text

A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13.

Bergman L, Silins G, Grimmond S, Hummerich H, Stewart C, Little P, Hayward N.

Genomics. 1999 Jan 1;55(1):49-56. PMID: 9888998 [PubMed - indexed for MEDLINE]

Characterization of the mouse Men1 gene and its expression during development.

Stewart C, Parente F, Piehl F, Farnebo F, Quincey D, Silins G, Bergman L, Carle GF, Lemmens I, Grimmond S, Xian CZ, Khodei S, Teh BT, Lagercrantz J, Siggers P, Calender A, Van de Vem V, Kas K, Weber G, Hayward N, Gaudray P, Larsson C.

Oncogene. 1998 Nov 12;17(19):2485-93. PMID: 9824159 [PubMed - indexed for MEDLINE]Free Article

Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism.

Teh BT, Kytölä S, Farnebo F, Bergman L, Wong FK, Weber G, Hayward N, Larsson C, Skogseid B, Beckers A, Phelan C, Edwards M, Epstein M, Alford F, Hurley D, Grimmond S, Silins G, Walters M, Stewart C, Cardinal J, Khodaei S, Parente F, Tranebjaerg L, Jorde R, Salmela P, et al.

Clin Endocrinol Metab. 1998 Aug;83(8):2621-6. PMID: 9709921 [PubMed - indexed for MEDLINE]Free Article

Molecular tools for presymptomatic testing in multiple endocrine neoplasia type 1.

Larsson C, Calender A, Grimmond S, Giraud S, Hayward NK, Teh B, Farnebo F.

Intern Med. 1995 Sep;238(3):239-44. PMID: 7673853 [PubMed - indexed for MEDLINE]

G protein mutations in tumours of the pituitary, parathyroid and endocrine pancreas.

Boothroyd CV, Grimmond SM, Cameron DP, Hayward NK.

Biochem Biophys Res Commun. 1995 Jun 26;211(3):1063-70. PMID: 7598693 [PubMed - indexed for MEDLINE]

Oesophageal cancer and Barrett’s oesophagus

High Intake of Folate from Food Sources Is Associated with Reduced Risk of Esophageal Cancer in an Australian Population.

Ibiebele TI, Hughes MC, Pandeya N, Zhao Z, Montgomery G, Hayward N, Green AC, Whiteman DC, Webb PM; for the Study of Digestive Health and Australian Cancer Study.

Nutr. 2011 Feb;141(2):274-283. Epub 2010 Dec 22. PMID: 21178085 [PubMed - as supplied by publisher]Free Article

High-risk human papillomavirus in esophageal squamous cell carcinoma.

Antonsson A, Nancarrow DJ, Brown IS, Green AC, Drew PA, Watson DI, Hayward NK, Whiteman DC; Australian Cancer Study.

Cancer Epidemiol Biomarkers Prev. 2010 Aug;19(8):2080-7. PMID: 20696664 [PubMed - indexed for MEDLINE]

Gene expression alterations in formalin-fixed, paraffin-embedded Barrett esophagus and esophageal adenocarcinoma tissues.

Botelho NK, Schneiders FI, Lord SJ, Freeman AK, Tyagi S, Nancarrow DJ, Hayward NK, Whiteman DC, Lord RV.

Cancer Biol Ther. 2010 Jul 15;10(2):172-9. Epub 2010 Jul 26. PMID: 20543560 [PubMed - in process]

Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers.

Whiteman DC, Parmar P, Fahey P, Moore SP, Stark M, Zhao ZZ, Montgomery GW, Green AC, Hayward NK, Webb PM; Australian Cancer Study.

Gastroenterology. 2010 Jul;139(1):73-83; quiz e11-2. Epub 2010 Apr 14 PMID: 20399210 [PubMed - indexed for MEDLINE]

Smith E, De Young NJ, Pavey SJ, Hayward NK, Nancarrow DJ, Whiteman DC, Smithers BM, Ruszkiewicz AR, Clouston AD, Gotley DC, Devitt PG, Jamieson GG, Drew PA.

Mol Cancer. 2008 Oct 2;7:75. PMID: 18831746 [PubMed - indexed for MEDLINE]Free PMC Article Free text

Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays.

Nancarrow DJ, Handoko HY, Smithers BM, Gotley DC, Drew PA, Watson DI, Clouston AD, Hayward NK, Whiteman DC.

Cancer Res. 2008 Jun 1;68(11):4163-72. PMID: 18519675 [PubMed - indexed for MEDLINE]Free Article

Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers.

Doecke JD, Zhao ZZ, Stark MS, Green AC, Hayward NK, Montgomery GW, Webb PM, Whiteman DC; Australian Cancer Study.

Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):1007-12. PMID: 18398047 [PubMed - indexed for MEDLINE]Free Article

Leptin and the risk of Barrett's oesophagus.

Kendall BJ, Macdonald GA, Hayward NK, Prins JB, Brown I, Walker N, Pandeya N, Green AC, Webb PM, Whiteman DC; Study of Digestive Health.

Gut. 2008 Apr;57(4):448-54. Epub 2008 Jan 4. PMID: 18178609 [PubMed - indexed for MEDLINE]