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Group Leader
Associate Professor Amanda Spurdle
Summary
The Molecular Cancer Epidemiology Laboratory studies breast and ovarian cancer, endometrial cancer, colon cancer and prostate cancer, with a focus on identifying molecular signatures of normal and tumour tissue that can point to the genetic and environmental causes of these cancers. The laboratory covers a range of projects with the themes of cancer epidemiology and molecular pathology.
Conditions researched
Current research
- The Australian National Endometrial Cancer Study (ANECS)
- Clinical classification of Mismatch Repair gene variants
- Clinical classification of BRCA1 and BRCA2 gene variants
- Breast and ovarian cancer predisposition and prognosis and modifier genes
- Prostate cancer predisposition and prognosis genes
- Breast and ovarian cancer predisposition and prognosis and modifier genes
Staff
Group Leader: Associate Professor Amanda Spurdle
Postdoctoral staff: Dr Jodie Painter, Dr Felicity Lose, Dr Tracy O’Mara, Dr Jyotsna Batra
Research Assistants: Michael Parsons, Alex Metcalf
PhD students: Bryony Thompson, Yen Tan, SriLakshmi Srinivasan
Funding
We gratefully acknowledge support from the following organisations and funding bodies:
- National Health and Medical Research Council
- Cancer Australia
Collaborators
ANECS (Australian National Endometrial Cancer Study)
ENIGMA consortium (Evidence-based Network for the Interpretation of Germline Mutant Alleles)
InSiGHT (International Society for Gastrointestinal Hereditary Tumours Incorporated)
kConFab (Kathleen Cuningham Foundation consortium for research into familial breast cancer)
BCAC consortium (Breast Cancer Association Consortium)
CIMBA consortium (Consortium of Investigators of Modifiers of BRCA1/2)
E2C2 (Epidemiology of Endometrial Cancer Consortium)
Professor Douglas Easton, Dr Alison Dunning and Prof Paul Pharoah, Cambridge University, UK
Professor David Goldgar and Associate Professor Sean Tavtigian, University of Utah, USA
Professor Fergus Couch, Mayo Clinic College of Medicine, USA
Professor Ian Tomlinson, University of Oxford, UK
Professor Xiao-Ou Shu, VanderBilt University, USA
Dr Logan Walker, University of Otago, New Zealand
Professor Melissa Brown, Prof Lakhani, University of Queensland
Professor Judith Clements, Queensland University of Technology
Dr Andreas Obermair, Royal Brisbane and Women's Hospital
Dr Jermaine Coward, Mater Medical Research Institute, Australia
Professor Georgia Chenevix-Trench, Cancer Genetics, QIMR
Dr Penny Webb and Dr Christina Nagle, Gynaecological Cancer Group, QIMR
