Bioinformatics

Team Head

Dr Lutz Krause

Summary

The Bioinformatics Laboratory develops and applies bioinformatics methods in the context of biomedical research. The laboratory specialises in genetics and epigenetics of complex disorders, biomarker discovery, parasite genomics, the human microbiota, and machine learning.

Conditions researched

• Parasite infections
• Genetic diseases
• Gastrointestinal disorders
• Respiratory tract infections
• Viral infections
• Cancer
• Psychiatric disorders
• Obesity
• Metabolic disorders

Current research

• Comparative genomics of human parasites, identification of vaccine and drug targets
• Discovery of biomarkers for prognosis, progression and personalised treatment in cancer
• Epigenetics in complex disorders
• Role of the human microbiota and viruses in health and disease
• Genome-wide association studies of genetic disorders
• Development of methods for integrating, mining and visualising heterogeneous datasets, including genomic variations, gene expression and epigenetic modifications
• Development of data-mining methods, machine learning techniques and algorithms for the analysis of microbial and viral metagenomes, epigenetic samples, whole genome association studies, next-generation sequence data

Student projects

Staff

Team Head: Dr Lutz Krause

Postdoctoral staff: Dr Jonathan Ellis

Masters student: Jasmin Straube

Collaborations

• Professor Grant Montgomery
• Professor Nick Martin
• Professor Greg Anderson
• Professor Graham Kay
• Professor Georgia Chenevix-Trench

• Professor Andrew Barbour, Prince Alexander Hospital
• Dr Ian Mackay, QPID Laboratory
• Professor Tim Spector, King’s College London
• Professor Luis Vitetta, The University of Queensland
• Professor Mark Morrison, CSIRO
• Professor Phil Hugenholtz, The University of Queensland
• Dr Sandrine Claus, Imperial Colleague London