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Group Leader
Dr Kelli MacDonald
Summary
The Antigen Presentation and Immunoregulation Laboratory aims to investigate how donor and host antigen presenting cells (APCs) respond following bone marrow stem cell transplantation. Basic research in immunology using preclinical models follows three streams: APC development, antigen presentation, and APC induced T cell responses and their regulation.Conditions researched
- Graft-versus-host disease
- Leukaemia and lymphoma
Current research
- Contribution of donor dendritic cells to immunosuppression which occurs following haematopoeitic stem cell transplantation
- Development of DC immunotherapy protocols for the attenuation of graft versus host disease
- Role of IL-17 and related family members in chronic GVHD
- Contribution of regulatory T cells to the development of chronic GHVD
Staff
Group Leader: Dr Kelli MacDonald
Postdoctoral staff: Dr Motoko Koyama, Dr Antiopi Varelias
Research Assistants: Rachel Kuns, Neil Raffelt, Alistair Don
PhD students: Kate Markey, Renee Robb
Funding
We gratefully acknowledge the support of the following funding agencies:
- Cancer Council Queensland
- Leukaemia Foundation Australia
- National Health and Medical Research Council
Collaborators
Professor Geoff Hill, Bone Marrow Transplantation Laboratory, QIMR
