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Group Leader
Dr Kelli MacDonald
Summary
The Antigen Presentation and Immunoregulation Laboratory aims to investigate the contribution of donor and host antigen presenting cells (APCs) to immune responses following bone marrow stem cell transplantation. Basic research in immunology using preclinical models follows three streams: APC development, antigen presentation, and APC induced T cell responses and their regulation.Conditions researched
- Graft-versus-host disease
- Leukaemia, lymphomas and myelomas
- Chronic liver disease
Current research
- Contribution of donor dendritic cells to immunosuppression which occurs following haematopoeitic stem cell transplantation
- Development of DC immunotherapy protocols for the attenuation of graft versus host disease (GVHD)
- Role of IL-17 and related family members in chronic GVHD
- Role of macrophages in GVHD
- Contribution of regulatory T cells to the development of chronic GVHD
Staff
Group Leader: Dr Kelli MacDonald
Research Officers: Kylie Alexander, Kate Gartlan
Research Assistants: Katie Lineburg, Stuart Olver
PhD students: Lucie Leveque, Melody Cheon
Funding
We gratefully acknowledge the support of the following funding agencies:
- Cancer Council Queensland
- Leukaemia Foundation Australia
- National Health and Medical Research Council
- The Atlantic Philanthropies
- Rio Tinto Ride to Conquer Cancer Flagship
Collaborators
Professor Geoff Hill, Bone Marrow Transplantation Laboratory, QIMR
Professor Andreas Suhrbier, Immunovirology, QIMR
Dr Steven Lane, Translational Leukaemia Research, QIMR
Dr Ashraful Haque, Malaria Immunology, QIMR
Tara Roberts, Radiation Biology and Oncology, QIMR
Professor Ranjeny Thomas, Diamantina Institute, University of Queensland, Brisbane, Australia
Professor David Hume, The Roslin Institute, Midlothian, UK
Dr Andrew Roberts, WEHI, Melbourne, Australia
Dr Gabrielle Belz, WEHI, Melbourne, Australia
Dr Jose Villandangos, WEHI, Melbourne, Australia
Dr John Hill, Amgen, Seattle, USA
Dr Andrew Clouston, Envoi Pathology, Brisbane, Australia
Dr Allison Pettit, UQCCR, University of Queensland, Brisbane, Australia
Dr Christine Wells, AIBN, University of Queensland, Brisbane, Australia
