Sib-pair Command: grr


ClassGlobal
Namegrr
Arguments <trait prevalence> <Frequency of A allele> <genotypic risk ratio> [add|dom|rec]
<trait prevalence> <Frequency of A allele in cases> <Frequency of A allele in controls> case-control

Calculates recurrence risks and segregation ratios under a diallelic generalized single major locus model specified via trait prevalence, ratio of penetrances and pattern of inheritance (codominant multiplicative, dominant or recessive).

If the case-control modifier is present, instead it expects the prevalence, risk allele frequency in cases, and risk allele frequency in controls. See sml for interpretation of the output.

Example:

>> grr 0.1 0.1 { 1.5 2 2.5 }
>> grr 0.1 0.2 0.1 case

------------------------------------------------
Single Major Locus Recurrence Risk Calculation
------------------------------------------------

 Frequency(A): 0.110000; Pen(AA): 0.331; Pen(AB): 0.163; Pen(BB): 0.081
 Trait Prev  : 0.100000; Pop AR:  19.2%; Var(Add): 0.001655; Var(Dom): 0.000068

 Measure      MZ Twin       Sib-Sib        Par-Off      Second
----------   ----------    ----------     ---------    ----------
 Rec risk         0.117         0.108         0.108         0.104
 Rel risk         1.195         1.095         1.093         1.046
 Odds rat         1.221         1.106         1.104         1.052
 PRR              1.172         1.084         1.083         1.041
 ibd|A-A          1.000         0.520         0.500         0.260
 ibd|A-U          1.000         0.498         0.500         0.249

 Freq of A if Affected: 0.200000 (0.040,0.320,0.640)
 Freq of A if Unaffctd: 0.100000 (0.009,0.182,0.809)

 Mating       Proportion    Risk to offspring
----------   -----------   ------------------
UnA x UnA         0.810         0.098
Aff x UnA         0.180         0.107
Aff x Aff         0.010         0.117

See also:

sml recurrence risks


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