Research & Technology Platforms

Genomics

• Information database on 30,000 twins and relatives
• DNA database on 5,000 twins
• Mass Array SNP typing facility
• Genome scans
• Zebrafish facility with many cutting edge methods for gene detection and analysis
• Gene expression profiling of cancer cell lines and tumours to identify novel diagnostic and prognostic markers for disease.
• cDNA library construction

Transgenic/Knockout Mice

• Generation of knockout and transgenic mice
• Mouse embryo freezing.
• Production of gene knockouts in specific tissues in mice.

Cancer Models

• Screening of compounds for anti-tumour activity against a panel of human cancer cell lines (cell growth and reporter gene assays)
• Mechanism of action of candidate anti-cancer drugs
• Mechanisms of gene regulation by agents, including use of microarray technology
• Monoclonal antibodies for research and diagnosis
• Xenograft models
• Models investigating human cancer susceptibility
• EBV models

Infectious Disease Models

• Investigation of the efficacy of vaccines or candidate drugs against infectious disease, including Malaria, Leishmania, Group A Streptococcus, Schistomiasis, Hook worms
• Viral protection assays
• Effects of compounds on viruses including alphaviruses, poxvirus (vaccinia) and herpes virus (cytomegalovirus)
• Evaluation of drug resistance

Immunological models

• "Graft-vs Host Disease" transplantation models
• Models evaluating anti-viral activity
• Effect of novel compounds, drugs, vaccines, immunosuppressants and immunostimulators on cytotoxic T lymphocytes (CTL's).
• In vitro and in vivo assays of activation of macrophages, NK cells, T cells, B cells, dendritic cells.
• FACs analysis

Cell & Tissue Biology

• Confocal, electron, and laser dissection microscopy
• Signal transduction assays
• Histology & Histopathology
• Cell Sorting

Statistics/Bioinformatics

Epidemiology

• Extensive resource to conduct nationwide studies on important diseases. We combine classical epidemiological methodology with genetic analysis of blood and tissue samples.

Contract Research and Development
Find out about QIMR's contract research capabilities.